| Primary Identifier | MGI:3044668 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 450219 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cardiolipin binding activity and wide pore channel activity. Involved in several processes, including hair follicle development; positive regulation of interleukin-1 beta production; and pyroptotic inflammatory response. Acts upstream of or within several processes, including hair follicle morphogenesis; negative regulation of timing of anagen; and regulation of signal transduction. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is active in membrane. Is expressed in foregut; hair root sheath; and hair shaft. Orthologous to human GSDMA (gasdermin A). PHENOTYPE: Mutations of this gene affect normal development of the hair follicle, resulting in abnormal coats. Some alleles are associated with corneal opacity and/or microphthalmia. For one allele, high rates of mutation are observed in the MHC that appear to be associated with intra-MHC recombination. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
