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Protein Coding Gene : Gsdma gasdermin A
Primary Identifier  MGI:1889509 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  57911
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptotic inflammatory response. Located in cytoplasm. Is expressed in foregut and skin. Orthologous to human GSDMA (gasdermin A).
PHENOTYPE: Mice homozygous for a null allele exhibit increased susceptibility to bacterial infection with a lack of pyroptosis. [provided by MGI curators]
  • synonyms:
  • gasdermin A,
  • MGI:2144607,
  • Gsdma1,
  • BB149167,
  • H312E,
  • gasdermin 1,
  • gasdermin A1,
  • Gsdm1,
  • expressed sequence BB149167,
  • Gsdma,
  • Gsdm
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