| Primary Identifier | MGI:2444210 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 217166 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity and E-box binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of neuroinflammatory response; and regulation of biosynthetic process. Acts upstream of or within circadian rhythm and regulation of DNA-templated transcription. Located in cytoplasm; dendritic spine; and nucleus. Is expressed in several structures, including alimentary system; connective tissue; genitourinary system; nervous system; and retina. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit altered circadian behavior and temperature regulation with mild alterations in cytoarchitecture of the cerebellum. Litter size is reduced by half in mutant females. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
