Primary Identifier | MGI:104768 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 14459 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway and response to food. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in gut. Orthologous to human GAST (gastrin). PHENOTYPE: Homozygotes for targeted null alleles exhibit an absence of gastric acid secretion, alterations in gastric architecture, fasting hypoglycemia with impaired glucagon response, and increased susceptibility to azoxymethane-induced colon tumors. [provided by MGI curators] |