| Primary Identifier | MGI:1261831 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15114 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including brain-derived neurotrophic factor binding activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including nervous system development; neurotrophin TRK receptor signaling pathway; and positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Acts upstream of or within vesicle transport along microtubule. Located in autophagosome; cytoplasmic vesicle; and microtubule organizing center. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study melancholic depression. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HAP1 (huntingtin associated protein 1). PHENOTYPE: Homozygous inactivation of this gene results in abnormal feeding and/or suckling behavior, absent gastric milk in neonates, slow postnatal weight gain, and postnatal death. Degeneration in hypothalamic regions that control feeding behavior has been observed. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
