Primary Identifier | MGI:1921657 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 74407 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; heart development; and outer dynein arm assembly. Located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Is expressed in node. Used to study primary ciliary dyskinesia 35. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). PHENOTYPE: Mice homozygous for a null allele display partial preweaning lethality, impaired ciliary motility, and a variety of left-right body symmetry defects. [provided by MGI curators] |