| Primary Identifier | MGI:103036 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20850 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; phosphate ion binding activity; and promoter-specific chromatin binding activity. Involved in growth hormone receptor signaling pathway via JAK-STAT. Acts upstream of with a positive effect on taurine metabolic process. Acts upstream of or within several processes, including positive regulation of leukocyte proliferation; regulation of hemopoiesis; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). PHENOTYPE: Mice homozygous for disruptions in this gene are reduced in size and display abnormalities in both mammary gland structure and function. Homozygosity for a phosphorylation-blocking mutation affects T cell proliferation and pregnancy-related mammary duct expansion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
