| Primary Identifier | MGI:103038 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20848 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and protein sequestering activity. Involved in several processes, including cell surface receptor signaling pathway; glial cell differentiation; and lymphocyte activation involved in immune response. Acts upstream of or within several processes, including mRNA transcription by RNA polymerase II; negative regulation of glycolytic process; and negative regulation of neuron migration. Located in plasma membrane. Part of transcription regulator complex. Is active in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hindlimb long bone. Used to study autosomal dominant hyper-IgE syndrome 1 with recurrent infections; colorectal cancer; inflammatory bowel disease; peripartum cardiomyopathy; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; arthritis (multiple); carcinoma (multiple); inflammatory bowel disease (multiple); and reproductive organ cancer (multiple). Orthologous to human STAT3 (signal transducer and activator of transcription 3). PHENOTYPE: Homozygotes for targeted null mutations die at embryonic day 6.5-7.5. Conditional, tissue specific mutants are variably viable and show diverse defects including obesity, diabetes, thermal dysregulation and infertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
