| Primary Identifier | MGI:105077 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15485 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; estradiol 17-beta-dehydrogenase [NAD(P)+] activity; and testosterone dehydrogenase [NAD(P)+] activity. Involved in estrogen biosynthetic process and testosterone biosynthetic process. Acts upstream of or within several processes, including adipose tissue development; lysosome organization; and skeletal muscle tissue development. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; reproductive system; spleen; submandibular gland; and trachea. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit severe female subfertility with defects in leteunization and progesterone production. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
