| Primary Identifier | MGI:1097695 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14055 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone H3K27 methyltransferase activity and transcription corepressor activity. Contributes to histone binding activity. Involved in facultative heterochromatin formation; negative regulation of transcription by RNA polymerase II; and subtelomeric heterochromatin formation. Acts upstream of or within hepatocyte homeostasis; liver regeneration; and response to tetrachloromethane. Located in chromosome, telomeric region; heterochromatin; and nucleus. Part of ESC/E(Z) complex. Is expressed in several structures, including genitourinary system; immune system; retina nuclear layer; tail; and trunk. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile, and healthy. Mice homozygous for a conditional allele activated in hematopoietic stem cells exhibit bone marrow failure with defective HSC maintenance and premature senescence. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
