| Primary Identifier | MGI:1859650 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 54409 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables coreceptor activity. Involved in several processes, including cell-cell junction assembly; circulatory system development; and negative regulation of endothelial cell apoptotic process. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of adrenomedullin receptor complex. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including central nervous system; forelimb bud; gut; heart; and prostate gland lobe. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality. Mice heterozygous for the null allele exhibit decreased litter size beyond the loss of homozygous embryos. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
