| Primary Identifier | MGI:1891828 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 56208 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and protein-macromolecule adaptor activity. Involved in autophagosome assembly; cellular response to glucose starvation; and engulfment of apoptotic cell. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of autophagosome assembly; and positive regulation of cardiac muscle hypertrophy. Located in autophagosome; phagocytic vesicle; and trans-Golgi network. Part of phosphatidylinositol 3-kinase complex, class III. Is active in cytoplasm. Is expressed in several structures, including brain; extraembryonic visceral endoderm; jaw; oral epithelium; and sensory organ. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to human BECN1 (beclin 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit premature death, increased tumor incidence and reduced autophagy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
