| Primary Identifier | MGI:96601 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 16399 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables extracellular matrix binding activity. Acts upstream of or within cell-matrix adhesion. Located in external side of plasma membrane and focal adhesion. Is expressed in several structures, including early conceptus; hematopoietic system; liver; mesenchyme derived from splanchnopleure; and umbilical blood vessel. Used to study platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b). PHENOTYPE: Homozygotes for targeted null mutations exhibit a bleeding disorder, lack platelet binding to fibrinogen, absence of fibrinogen in platelet alpha granules, and increased numbers of hematopoietic progenitors in yolk sac, fetal liver, and bone marrow. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
