| Primary Identifier | MGI:1888994 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 57778 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including GTPase activating protein binding activity; profilin binding activity; and small GTPase binding activity. Involved in actin filament severing. Acts upstream of or within substrate-dependent cell migration. Located in cytosol; phagocytic vesicle; and plasma membrane. Is expressed in several structures, including gut; heart; immune system; liver; and lung. Orthologous to human FMNL1 (formin like 1). PHENOTYPE: One constitutive homozygous KO allele is embryonic lethal, another is viable but leads to impaired T cell trafficking to inflammation sites. Conditional homozygous KO in myeloid cells leads to reduced macrophage migration and podosome formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
