| Primary Identifier | MGI:88498 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 12921 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables corticotrophin-releasing factor receptor activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; corticotropin secretion; and regulation of corticosterone secretion. Acts upstream of or within behavioral response to ethanol; exploration behavior; and general adaptation syndrome, behavioral process. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including Leydig cell; brain; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including CRHR1 (corticotropin releasing hormone receptor 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit agenesis of the adrenal zona fasciculata, low adrenocorticotropic hormone production, and reduced anxiety-related behaviors. Progeny of homozygote matings die from lung dysplasia within 48 hours of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
