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Protein Coding Gene : Mettl2 methyltransferase 2, methylcytidine
Primary Identifier  MGI:1289171 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  52686
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; heart; respiratory system; and sensory organ. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced 3-methylcytidine (m3C) methyltransferases modification of tRNA. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2810438F06 gene,
  • MGI:2442741,
  • expressed sequence AW493404,
  • AW493404,
  • C130031G21Rik,
  • MGI:2144544,
  • 2810438F06Rik,
  • methyltransferase 2, methylcytidine,
  • RIKEN cDNA C130031G21 gene,
  • D11Ertd768e,
  • Mettl2,
  • DNA segment, Chr 11, ERATO Doi 768, expressed,
  • PSENIP1,
  • MGI:1920002
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