| Primary Identifier | MGI:1919399 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 72149 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to contribute to protein serine/threonine kinase activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of intracellular protein-containing complex and serine/threonine protein kinase complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular zone; cortical plate; and thymus primordium. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). PHENOTYPE: Mice homozygous for a null allele exhibit incomplete postnatal lethality, decreased body size, domed skulls, malocclusion of incisors, hypotonia, tremors, enlarged brain ventricles, and abnormal neuron migration with ectopic neurons. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
