Primary Identifier | MGI:96431 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 15985 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and transmembrane signaling receptor activity. Involved in B cell receptor signaling pathway. Acts upstream of or within response to bacterium. Located in external side of plasma membrane. Part of B cell receptor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in agammaglobulinemia 6 and lymphoma (multiple). Orthologous to human CD79B (CD79b molecule). PHENOTYPE: Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor. [provided by MGI curators] |