| Primary Identifier | MGI:3046173 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 445007 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable CCR2 chemokine receptor binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within lamellipodium assembly and macrophage chemotaxis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including blastocyst; cerebral cortex ventricular layer; early embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in nephrotic syndrome type 17. Orthologous to human NUP85 (nucleoporin 85). PHENOTYPE: Inducible KO decreases macrophage and monocyte population in tumors, reducing tumor growth and metastasis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
