| Primary Identifier | MGI:95805 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14784 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including enzyme binding activity; ephrin receptor binding activity; and guanyl-nucleotide exchange factor adaptor activity. Involved in cell surface receptor signaling pathway and nervous system development. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Located in several cellular components, including cell-cell junction; plasma membrane; and vesicle membrane. Part of COP9 signalosome. Is active in cell cortex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). PHENOTYPE: Embryos homozygous for a targeted null mutation lack expanded inner cell masses, show only a few endodermal cells, and die by embryonic day 7.5. Heterozygotes have defective T cell signaling and lack the cardiac hypertrophy response to pressure overload. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
