Primary Identifier | MGI:1101768 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 15081 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Acts upstream of or within several processes, including constitutive heterochromatin formation; germ cell development; and regulation of chromosome organization. Located in nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and leg muscle. Orthologous to human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B). PHENOTYPE: Mice heterozygous for a reporter allele exhibit reduced body size and male infertility due to failure of spermiogenesis. [provided by MGI curators] |