| Primary Identifier | MGI:2442815 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 338364 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin-protein transferase activity. Involved in protein K63-linked ubiquitination. Acts upstream of or within several processes, including innate immune response; positive regulation of protein oligomerization; and positive regulation of type I interferon production. Located in cytoplasm. Orthologous to human TRIM65 (tripartite motif containing 65). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to Picornaviridae infection and associated morbidity/mortality, with markedly decreased circulating type I interferon levels following infection with encephalomyocarditis virus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
