Primary Identifier | MGI:2684912 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 217341 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in cell projection assembly; flagellated sperm motility; and negative regulation of ubiquitin-dependent protein catabolic process. Located in cytoplasm; nucleus; and sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 35. Orthologous to human QRICH2 (glutamine rich 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with decreased epididymis weight, multiple morphological abnormalities of the sperm flagella, oligozoospermia, and asthenozoospermia. [provided by MGI curators] |