| Primary Identifier | MGI:2444266 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 217342 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Predicted to be located in cytoplasm and nuclear body. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; genitourinary system; and immune system. Orthologous to human UBE2O (ubiquitin conjugating enzyme E2 O). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased MEF proliferation and transformation and increased pre-weaning lethality. Mice heterozygous for the allele exhibit increased total body fat amount, increased startle reflex, increased grip strength and increased circulating HDL cholesterol. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
