| Primary Identifier | MGI:2669037 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 217356 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mechanosensitive monoatomic ion channel activity; protein sequestering activity; and tumor necrosis factor binding activity. Involved in protein stabilization. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC8 (transmembrane channel like 8). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no major defects in T cell subset numbers or function. [provided by MGI curators] |