| Primary Identifier | MGI:98753 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 21858 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired activation of pro-matrix metalloproteinase-2, but appear phenotypically normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
