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Protein Coding Gene : Rbfox3 RNA binding protein, fox-1 homolog (C. elegans) 3
Primary Identifier  MGI:106368 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  52897
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables DNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus and perikaryon. Is expressed in dorsal root ganglion; nervous system; and sensory organ. Orthologous to human RBFOX3 (RNA binding fox-1 homolog 3).
PHENOTYPE: Mice homozygous for a null allele exhibit reduced brain weight, increased susceptibility kainic acid-induced seizures, decreased anxiety-related behaviors, and deficits in synaptic transmission and plasticity in the dentate gyrus. [provided by MGI curators]
  • synonyms:
  • Neuna60,
  • MGD-MRK-34061,
  • DNA segment, Chr 11, Brigham & Women's Genetics 0517 expressed,
  • NeuN,
  • MGI:1929613,
  • Hrnbp3,
  • RNA binding protein, fox-1 homolog (C. elegans) 3,
  • Rbfox3,
  • D11Bwg0517e,
  • neuronal nuclear antigen A60
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