| Primary Identifier | MGI:2385849 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 209011 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables NAD-dependent protein-lysine depropionylase activity and histone H3K18 deacetylase activity, NAD-dependent. Involved in several processes, including chromatin remodeling; homologous chromosome pairing at meiosis; and protein deacylation. Located in chromatin and site of double-strand break. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; eye; gonad; and pancreas. Orthologous to human SIRT7 (sirtuin 7). PHENOTYPE: Mice homozygous for a null allele exhibit premature aging and death associated with inflammatory, degenerative cardiac hypertrophy and cardiac fibrosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
