| Primary Identifier | MGI:2384805 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 209588 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity. Predicted to be involved in immune response and signal transduction. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in membrane. Is expressed in cortical plate. Orthologous to human SECTM1 (secreted and transmembrane 1). PHENOTYPE: Homozygous null mice show increased mortality and cardiac injury after LPS injection, with increased inflammatory macrophages in hearts and inflammatory cytokine levels in macrophages, serum and hearts. High-fat feeding results in increased heart inflammation and worsened cardiac function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
