| Primary Identifier | MGI:1914090 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 66840 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable TSC1-TSC2 complex binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion; cellular response to starvation; and macroautophagy. Predicted to be located in lysosome and phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WDR45B (WD repeat domain 45B). PHENOTYPE: Conditional homozygous knockout in neurons affects the Golgi apparatus and mitochondria, which impairs alternative autophagy and leads to neuronal degeneration in the brain and motor deficits. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
