| Primary Identifier | MGI:2442210 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 319530 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within establishment of skin barrier; membrane biogenesis; and positive regulation of biosynthetic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; ganglia; salivary gland primordium; sensory organ; and skin. Orthologous to human ZNF750 (zinc finger protein 750). PHENOTYPE: Mice homozygous for a knock-out allele die shortly after birth with absent eyelids and exhibit shiny, wrinkled skin, dehydration, weight loss, thin epidermis, impaired skin barrier function, and alterations in epidermal terminal differentiation and lipid composition. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
