| Primary Identifier | MGI:97742 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 18976 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables hormone activity. Involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of oxytocin production; and response to melanocyte-stimulating hormone. Acts upstream of or within several processes, including glucose homeostasis; regulation of corticosterone secretion; and regulation of glycogen metabolic process. Located in extracellular space and secretory granule. Is expressed in several structures, including alimentary system; nervous system; oviduct; skeletal musculature; and skin. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin). PHENOTYPE: Homozygotes for a targeted null mutation are obese and exhibit abnormal hormone levels, abnormal pigmentation, increased food intake, and adiposity. Mice homozygous for another knock-out allele exhibit altered reward based behavior and immune response toLPS treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
