Primary Identifier | MGI:1923800 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 52504 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in chromosome segregation. Predicted to be located in nuclear body. Predicted to be part of Mis6-Sim4 complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; sensory organ; and thymus primordium. Orthologous to human CENPO (centromere protein O). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5. [provided by MGI curators] |