Primary Identifier | MGI:1338049 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 20403 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable molecular adaptor activity. Acts upstream of or within cell-cell signaling and endocytosis. Is active in cytosol. Is expressed in several structures, including endocrine gland; hemolymphoid system; ileum; male reproductive gland or organ; and nervous system. Used to study nephrotic syndrome. Orthologous to human ITSN2 (intersectin 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal brain morphology and function and behavior. Mice lacking the long isoform exhibit delayed recovery from LPS-induced kidney injury. [provided by MGI curators] |