Primary Identifier | MGI:3583946 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 432628 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sphingolipid transporter activity. Involved in lipid transport; positive regulation of platelet aggregation; and sphingosine-1-phosphate receptor signaling pathway. Is active in plasma membrane. Is expressed in liver lobe. Orthologous to human MFSD2B (MFSD2 lysolipid transporter B, sphingolipid). PHENOTYPE: Homozygous KO reduces sphingosine-1-phosphate export from, and increases its accumulation in, red blood cells and platelets, and leads to reduced leukocyte, reticulocyte, and erythrocyte cell numbers. [provided by MGI curators] |