Primary Identifier | MGI:2443149 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 209334 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including DNA endonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA metabolic process and regulation of cell cycle process. Predicted to be located in centrosome. Is expressed in embryo; heart; metanephros; nephric duct; and neural tube. Orthologous to human GEN1 (GEN1 Holliday junction 5' flap endonuclease). PHENOTYPE: Mice homozygous for a hypomorphic allele exhibit abnormal kidney and urinary tract development. [provided by MGI curators] |