| Primary Identifier | MGI:1919103 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 71853 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-disulfide reductase activity. Involved in negative regulation of IRE1-mediated unfolded protein response. Part of endoplasmic reticulum chaperone complex. Is expressed in embryo; heart; liver; lung epithelium; and pancreas epithelium. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6). PHENOTYPE: Mice homozygous for a null allele exhibit preweaning lethality. Mice homozygous for a hypomorphic allele exhibit reduced body weight and impaired T cell-independent and dependent antibody responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
