| Primary Identifier | MGI:2182540 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 195733 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription cis-regulatory region binding activity. Involved in epidermis development. Acts upstream of or within desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human GRHL1 (grainyhead like transcription factor 1). PHENOTYPE: Mice homozygous for a null allele display alopecia or sparse hair, abnormal hair follicle root sheaths, thickening of the cornified layer on the paws, and postnatal growth retardation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
