Primary Identifier | MGI:1924730 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 77480 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable PDZ domain binding activity; protein kinase binding activity; and protein kinase regulator activity. Acts upstream of or within dendrite morphogenesis and in utero embryonic development. Predicted to be located in late endosome. Predicted to be part of protein-containing complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human KIDINS220 (kinase D interacting substrate 220). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for a knock-out allele exhibit decreased dendritic complexity in the barrel somatosensory cortex and dentate gyrus neurons. [provided by MGI curators] |