| Primary Identifier | MGI:1100511 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 17933 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II; neuron development; and neuron fate specification. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; nervous system; and olfactory epithelium. Used to study autosomal dominant intellectual developmental disorder 39. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Orthologous to human MYT1L (myelin transcription factor 1 like). PHENOTYPE: Homozygous null mice show neonatal lethality. Heterozygous pups show altered communication while adults become overweight, show hyperactivity due to impaired habituation, reduced motor performance and anxiety, enhanced startle reflex and nest building, and impaired contextual conditioning behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
