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Protein Coding Gene : Pxdn peroxidasin
Primary Identifier  MGI:1916925 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  69675
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables oxidoreductase activity, acting on peroxide as acceptor. Involved in basement membrane assembly; cell adhesion; and eye development. Located in basement membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; heart; and sensory organ. Human ortholog(s) of this gene implicated in anterior segment dysgenesis 7. Orthologous to human PXDN (peroxidasin).
PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit abnormal eye development with early-onset glaucoma and progressive retinal dysgenesis. [provided by MGI curators]
  • synonyms:
  • C85409,
  • mKIAA0230,
  • MGI:2145116,
  • expressed sequence C85409,
  • Pxdn,
  • RIKEN cDNA 2310075M15 gene,
  • 2310075M15Rik,
  • peroxidasin,
  • VPO1
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