| Primary Identifier | MGI:3697448 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 100294583 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein tyrosine kinase activator activity and signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron projection development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human ALKAL2 (ALK and LTK ligand 2). PHENOTYPE: Homozygous deletion of this gene results in slow postnatal weight gain, thin body, decreased adiposity, and leanness coupled to increased energy expenditure and respiratory exchange ratio, hyperactivity, improved glucose tolerance and sensitivity to insulin, and decreased susceptibility to diet-induced obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
