| Primary Identifier | MGI:2150010 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 114712 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including floor plate development; regulation of dopaminergic neuron differentiation; and regulation of neurogenesis. Located in nucleus. Is expressed in several structures, including central nervous system; eye; future midbrain; genitourinary system; and liver. Orthologous to human FERD3L (Fer3 like bHLH transcription factor). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired caudal neural tube floor plate neuron maturation and reduced mesencephalic dopaminergic neurons. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
