| Primary Identifier | MGI:1344405 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 23795 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable dystroglycan binding activity; epidermal growth factor receptor binding activity; and protein homodimerization activity. Involved in digestive tract morphogenesis; mucus secretion; and positive regulation of developmental growth. Acts upstream of or within inflammatory response and lung goblet cell differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; gut; liver; and lung. Orthologous to human AGR2 (anterior gradient 2, protein disulphide isomerase family member). PHENOTYPE: Mice homozygous for one of several knock-out alleles exhibit reduced preweaning survival, abnormal gastrointestial morphology affecting secretory cell lineages, and increased susceptibility to induced colitis to varying degrees. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
