Primary Identifier | MGI:1914702 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 67452 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-independent phospholipase A2 activity. Involved in cardiolipin metabolic process; regulation of cellular response to oxidative stress; and triglyceride homeostasis. Located in mitochondrion and peroxisome. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). PHENOTYPE: Mice homozygous for a null allele exhibit some female-specific embryonic lethality, reduced body weight and temperature, cold intolerance, decreased exercise tolerance and decreased mitochondria function. [provided by MGI curators] |