| Primary Identifier | MGI:99879 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 18760 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of NLRP3 inflammasome complex assembly; positive regulation of osteoblast differentiation; and positive regulation of protein import into nucleus. Acts upstream of or within regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including cell cortex; cell-cell junction; and trans-Golgi network. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human PRKD1 (protein kinase D1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial embryonic lethality. Mice homozygous for a knock-in allele display partial embryonic and perinatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
