Primary Identifier | MGI:1351610 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 27386 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein heterodimerization activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within locomotory behavior; maternal behavior; and startle response. Located in nucleus. Is expressed in several structures, including central nervous system; heart and pericardium; salivary gland; sensory organ; and urinary system. Orthologous to human NPAS3 (neuronal PAS domain protein 3). PHENOTYPE: Mice homozygous for some knock-out alleles exhibit abnormal behavior and nervous system morphology. Mice homozygous for another knock-out allele exhibit defective lung branching morphogenesis and die shortly after birth. [provided by MGI curators] |