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Protein Coding Gene : Snx6 sorting nexin 6
Primary Identifier  MGI:1919433 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  72183
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables type I transforming growth factor beta receptor binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in glutamatergic synapse and postsynaptic early endosome. Is expressed in brain; cerebral cortex ventricular layer; and cortical plate. Orthologous to human SNX6 (sorting nexin 6).
PHENOTYPE: Mice homozygous for a conditional allele activated in neurons exhibit impaired spatial learning and memory, decreased dendritic spine density in CA1 neurons, and reduced AMPA-mediated eEPSCs. [provided by MGI curators]
  • synonyms:
  • AU018928,
  • 2610032J07Rik,
  • 2010006G21Rik,
  • RIKEN cDNA 2610032J07 gene,
  • MGI:1917093,
  • MGI:2144946,
  • expressed sequence C85963,
  • sorting nexin 6,
  • expressed sequence AU018928,
  • MGI:1916480,
  • MGI:2145122,
  • RIKEN cDNA 2010006G21 gene,
  • 2810425K19Rik,
  • Snx6,
  • RIKEN cDNA 2810425K19 gene,
  • C85963
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