| Primary Identifier | MGI:101763 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 12632 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables actin filament binding activity. Involved in actin filament fragmentation and skeletal muscle tissue development. Acts upstream of or within actin filament organization; muscle cell cellular homeostasis; and sarcomere organization. Predicted to be located in Z disc. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including heart; musculature; myotome; neural retinal epithelium; and testis. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal growth retardation and lethality associated with muscle weakness and skeletal muscle fiber degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
