| Primary Identifier | MGI:1270158 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 18094 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesoderm; liver; and lung epithelium. Orthologous to human NKX2-8 (NK2 homeobox 8). PHENOTYPE: Mutant mice lacking both functional copies of the gene are viable and fertile but display abnormal development of the spinal accessory nerve. Another mutant exhibits progressive bronchial dysplasia leading to lung cancer in aged mutants. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
